| 中文名称 |
Purified Anti-Human CD74 Antibody[LN2] |
| 英文名称 |
Purified Anti-Human CD74 Antibody[LN2] |
| 反应性 |
Human |
| 克隆编号 |
LN2 |
| 亚型 |
Mouse IgG1, κ |
| 经过验证的样品 |
Verified Samples in FCM: Human peripheral blood lymphocytes |
| 稀释 |
FCM 2 μg/mL(1×105-5×105cells) |
| Swissprot |
P04233 |
| 纯化方法 |
>98%, Protein A/G purified |
| 研究领域 |
Immunology |
| 共轭 |
Unconjugated |
| 存储缓冲区 |
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| 免疫原 |
Recombinant Human CD74 protein |
| 应用范围 |
FCM |
| 宿主 |
Mouse |
| 克隆性 |
Monoclonal |
| 储存条件 |
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| 有效期 |
12个月 |
CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.
经理
业务员小张
业务员小谭
业务员小罗
微信公众号
