| 中文名称 |
Purified Anti-Human CD57 Antibody[HNK-1] |
| 英文名称 |
Purified Anti-Human CD57 Antibody[HNK-1] |
| 反应性 |
Human |
| 克隆编号 |
HNK-1 |
| 亚型 |
Mouse IgM, κ |
| 经过验证的样品 |
Verified Samples in FCM: Human peripheral blood lymphocytes |
| 稀释 |
FCM 2 μg/mL(1×105-5×105cells) |
| Swissprot |
Q9P2W7 |
| 研究领域 |
Costimulatory Molecules;Immunology |
| 共轭 |
Unconjugated |
| 存储缓冲区 |
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| 应用范围 |
FCM |
| 宿主 |
Mouse |
| 克隆性 |
Monoclonal |
| 储存条件 |
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| 有效期 |
12个月 |
CD57, also known as HNK-1, NK-1, and Leu-7 is a 100-115 kD oligosaccharide antigenic determinant expressed on a variety of proteins, lipids, and chondroitin sulfate proteoglycans. CD57 is expressed on a subset of peripheral blood lymphocytes, including NK cells and CD8+ T cells, and is also expressed on neural cells and striated muscle. CD57 is not expressed on red blood cells, granulocytes, monocytes, or platelets. While the function of CD57 is unknown, binding to L-selectin, P-selectin, and a fragment of laminin suggests that CD57 may be involved in cell-matrix interactions. CD57 is increased in some disease states associated with CD4/CD8 imbalances (AIDS, autoimmune disease, viral infections, and allograft transplants).
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