| 中文名称 |
Purified Anti-Human CD62L Antibody[DREG56] |
| 英文名称 |
Purified Anti-Human CD62L Antibody[DREG56] |
| 反应性 |
Human |
| 克隆编号 |
DREG56 |
| 亚型 |
Mouse IgG1, κ |
| 经过验证的样品 |
Verified Samples in FCM: Human peripheral blood lymphocytes |
| 稀释 |
FCM 2 μg/mL(1×105-5×105cells) |
| Swissprot |
P14151 |
| 研究领域 |
Cell Adhesion;Cell Biology;Costimulatory Molecules;Immunology;Innate Immunity |
| 共轭 |
Unconjugated |
| 存储缓冲区 |
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| 应用范围 |
FCM |
| 宿主 |
Mouse |
| 克隆性 |
Monoclonal |
| 储存条件 |
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| 有效期 |
12个月 |
CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naive T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naive, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.
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