| 中文名称 |
PTPRK MS Standard C13 and N15-labeled recombinant protein (NP_001129120) |
| 英文名称 |
PTPRK MS Standard C13 and N15-labeled recombinant protein (NP_001129120) |
| 观察到的分子量 |
163 kDa |
| 缓冲区 |
25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| 序列 |
[RC227943] |
| 宿主 |
HEK293 |
| 来源 |
Human |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
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