| 中文名称 |
NDE1 MS Standard C13 and N15-labeled recombinant protein (NP_001137451) |
| 英文名称 |
NDE1 MS Standard C13 and N15-labeled recombinant protein (NP_001137451) |
| 观察到的分子量 |
37.7 kDa |
| 缓冲区 |
25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| 序列 |
[RC227919] |
| 宿主 |
HEK293 |
| 来源 |
Human |
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]