| 中文名称 |
NEDD4L MS Standard C13 and N15-labeled recombinant protein (NP_001138436) |
| 英文名称 |
NEDD4L MS Standard C13 and N15-labeled recombinant protein (NP_001138436) |
| 观察到的分子量 |
98.2 kDa |
| 缓冲区 |
25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| 序列 |
[RC227866] |
| 宿主 |
HEK293 |
| 来源 |
Human |
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
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业务员小张
业务员小谭
业务员小罗
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