| 中文名称 |
A2BP1 MS Standard C13 and N15-labeled recombinant protein (NP_061193) |
| 英文名称 |
A2BP1 MS Standard C13 and N15-labeled recombinant protein (NP_061193) |
| 观察到的分子量 |
42.6 kDa |
| 缓冲区 |
25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| 序列 |
[RC217960] |
| 宿主 |
HEK293 |
| 来源 |
Human |
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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