| 中文名称 |
A2M MS Standard C13 and N15-labeled recombinant protein (NP_000005) |
| 英文名称 |
A2M MS Standard C13 and N15-labeled recombinant protein (NP_000005) |
| 观察到的分子量 |
163.3 kDa |
| 缓冲区 |
25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| 序列 |
[RC207905] |
| 宿主 |
HEK293 |
| 来源 |
Human |
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
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