中文名称 |
Anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI5C5 (formerly 5C5), HRP conjugated |
英文名称 |
Anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI5C5 (formerly 5C5), HRP conjugated |
反应性 |
Human, Mouse, Rat |
纯化方法 |
Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
同种型 |
IgG1 |
缓冲区 |
PBS (pH 7.3) containing 1% BSA, 50% glycerol. |
检测范围 |
87.0 kDa |
灵敏度 |
Human, Mouse, Rat |
免疫原 |
Full length human recombinant protein of human APP (NP_000475) produced in HEK293T cell. |
应用范围 |
IHC, WB |
宿主 |
Mouse |
克隆性 |
Monoclonal |
物种 |
Mouse |
储存条件 |
Store at -20°C as received. |
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.