| 中文名称 |
(KO Validated) BAX Polyclonal Antibody |
| 英文名称 |
(KO Validated) BAX Polyclonal Antibody |
| 英文别名 |
BAX, BCL2L4 |
| 反应性 |
Human;Mouse;Rat |
| 应用性 |
WB;IHC |
| 经过验证的样品 |
Verified Samples in WB: 293T, 293T, HeLa, Raji, RAW264.7, Mouse lungVerified Samples in IHC: Rat ovary, Human lung cancer, Human breast cancer, Human stomach, Mouse liver, Mouse kidney |
| 纯化方法 |
Affinity purification |
| 共轭 |
Unconjugated |
| 计算分子量 |
4 kDa/12 kDa/15 kDa/18 kDa/19 kDa/21 kDa/24 kDa |
| 观察到的分子量 |
20 kDa |
| 细胞定位 |
Cytoplasm and Mitochondrion membrane. Cytoplasm. Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane. |
| 缓冲区 |
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
| 免疫原 |
A synthetic peptide of human BAX (NP_620116.1). |
| 应用范围 |
Cancer, Cell Biology, Metabolism |
| 宿主 |
Rabbit |
| 克隆性 |
Polyclonal |
| 储存条件 |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
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