| 中文名称 |
(KO Validated) CCND3 Polyclonal Antibody |
| 英文名称 |
(KO Validated) CCND3 Polyclonal Antibody |
| 英文别名 |
CCND3, Cyclin D3, cyclin D3 |
| 反应性 |
Human;Mouse |
| 应用性 |
WB |
| 经过验证的样品 |
Verified Samples in WB: HeLa, HeLa, K562, Mouse spleen |
| 纯化方法 |
Affinity purification |
| 共轭 |
Unconjugated |
| 计算分子量 |
9 kDa/22 kDa/24 kDa/32 kDa |
| 观察到的分子量 |
36 kDa |
| 细胞定位 |
Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. |
| 缓冲区 |
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
| 免疫原 |
Recombinant fusion protein of human CCND3 (NP_001751.1). |
| 应用范围 |
Cancer, Cell Biology, Epigenetics and Nuclear Signaling |
| 宿主 |
Rabbit |
| 克隆性 |
Polyclonal |
| 储存条件 |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
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