| 中文名称 |
(KO Validated) STAT3 Polyclonal Antibody |
| 英文名称 |
(KO Validated) STAT3 Polyclonal Antibody |
| 英文别名 |
ADMIO, ADMIO1, APRF, HIES, STAT3, Stat3 |
| 反应性 |
Human;Mouse;Rat |
| 应用性 |
WB;IF |
| 经过验证的样品 |
Verified Samples in WB:HeLa, 293TVerified Samples in IF: Rat brain, Mouse brain |
| 纯化方法 |
Affinity purification |
| 共轭 |
Unconjugated |
| 计算分子量 |
83 kDa/87 kDa/88 kDa |
| 观察到的分子量 |
90 kDa |
| 细胞定位 |
Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1. |
| 缓冲区 |
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
| 免疫原 |
Recombinant fusion protein of human STAT3 (NP_644805.1). |
| 应用范围 |
Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Developmental Biology, Signal Transduction, Stem Cells |
| 宿主 |
Rabbit |
| 克隆性 |
Polyclonal |
| 储存条件 |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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