| 中文名称 |
(KO Validated) Caspase-3 Polyclonal Antibody |
| 英文名称 |
(KO Validated) Caspase-3 Polyclonal Antibody |
| 英文别名 |
Active Caspase 3, CASP3, CPP32, CPP32B, Caspase 3, Caspase-3 p12, SCA-1, active Caspase-3, caspase-3 |
| 反应性 |
Human;Mouse;Rat |
| 应用性 |
WB;IHC |
| 经过验证的样品 |
Verified Samples in WB: Jurkat, 293TVerified Samples in IHC: Rat spleen, Human tonsil |
| 纯化方法 |
Affinity purification |
| 共轭 |
Unconjugated |
| 计算分子量 |
31 kDa |
| 观察到的分子量 |
17 kDa/35 kDa |
| 细胞定位 |
Cytoplasm. |
| 缓冲区 |
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
| 免疫原 |
Recombinant fusion protein of human Caspase-3 (NP_004337.2). |
| 应用范围 |
Cancer, Cell Biology, Metabolism, Neuroscience |
| 宿主 |
Rabbit |
| 克隆性 |
Polyclonal |
| 储存条件 |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
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