| 中文名称 |
(KO Validated) HuR / ELAVL1 Polyclonal Antibody |
| 英文名称 |
(KO Validated) HuR / ELAVL1 Polyclonal Antibody |
| 英文别名 |
ELAV1, ELAVL1, HUR, HuR / ELAVL1, Hua, MelG |
| 反应性 |
Human;Mouse;Rat |
| 应用性 |
WB;IHC;IF |
| 经过验证的样品 |
Verified Samples in WB: U-251MG, 293T, HeLa, Jurkat, K562, PC-3Verified Samples in IHC: Mouse testis, Mouse kidney, Rat testis, Human kidney cancer, Human esophageal cancerVerified Samples in IF: MCF-7 |
| 纯化方法 |
Affinity purification |
| 共轭 |
Unconjugated |
| 计算分子量 |
36 kDa/38 kDa |
| 观察到的分子量 |
37 kDa |
| 细胞定位 |
Cytoplasm. |
| 缓冲区 |
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3. |
| 免疫原 |
Recombinant fusion protein of human HuR / ELAVL1 (NP_001410.2). |
| 应用范围 |
Cancer, Epigenetics and Nuclear Signaling |
| 宿主 |
Rabbit |
| 克隆性 |
Polyclonal |
| 储存条件 |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
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