| 中文名称 |
14-3-3 epsilon Polyclonal Antibody |
| 英文名称 |
14-3-3 epsilon Polyclonal Antibody |
| 英文别名 |
14 3 3 E, 14 3 3 epsilon, 14 3 3E, 14-3-3 protein epsilon, 14-3-3E, 1433E, Epididymis luminal protein 2, FLJ45465, FLJ53559, HEL2, KCIP 1, KCIP1, MDCR, MDS, Mitochondrial import stimulation factor L subunit, Protein kinase C inhibitor protein1, Tyrosine 3 monooxygenase/t |
| 反应性 |
Human;Mouse;Rat |
| 应用性 |
WB;IHC |
| 经过验证的样品 |
Verified Samples in WB: Human brain malignant glioma, Human laryngocarcinomaVerified Samples in IHC: Human colon cancer, Human lung cancer |
| 纯化方法 |
Affinity purification |
| 共轭 |
Unconjugated |
| 计算分子量 |
29 kDa |
| 细胞定位 |
Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| 缓冲区 |
PBS with 0.05% sodium azide and 50% glycerol, pH 7.4. |
| 免疫原 |
Synthetic peptide of human YWHAE |
| 应用范围 |
Cancer, Neuroscience, Signal Transduction, Stem Cells |
| 宿主 |
Rabbit |
| 克隆性 |
Polyclonal |
| 储存条件 |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins.This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog.It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity.It has also been implicated in the pathogenesis of small cell lung cancer.Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
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